Most Read

    Published in last 1 year |  In last 2 years |  In last 3 years |  All
    Please wait a minute...
    For Selected: Toggle Thumbnails
    Evaluation Criteria and Rationality Analysis of Drug Utilization of Meropenem in a Tertiary Medical Institution in Beijing
    Zhang Qiming, Huang Zhe
    Asian Journal of Social Pharmacy    2025, 20 (1): 1-9.  
    Abstract218)      PDF(pc) (386KB)(643)       Save
    Objective To establish a drug use evaluation (DUE) standard for meropenem in a tertiary medical institution in Beijing, and to analyze the use of meropenem for promoting the rational use of antibiotics. Methods A criteria of DUE of meropenem was established based on drug instructions, related guidelines and experts’ opinions. Then, 120 cases of meropenem use from January to December 2021 were selected to carry out a retrospective study. Results and Conclusion 120 cases of meropenem use involved 8 clinical departments, including 38 cases in the Department of Respiratory Medicine, 25 cases in the Department of Tuberculosis, and 20 cases in the Department of Gastroenterology. The detection rate of pathogenic microorganisms before first use was 79.17%, and the clinical treatment effectiveness rate was 81.67%. The irrational use of meropenem included poor grasp of usage indications, excessively high starting points, inappropriate usage and dosage, non-standard treatment courses, and excessive combination medication. Pharmacists should strengthen the monitoring and evaluation of carbapenem drugs such as meropenem, provide timely feedback on relevant situations, and promote rational clinical medication.
    Related Articles | Metrics | Comments0
    Research on the Development Status, Problems and Countermeasures of Sports and Fitness APPs
    Xiu Yu, Wang Shuling
    Asian Journal of Social Pharmacy    2025, 20 (1): 88-93.  
    Abstract203)      PDF(pc) (380KB)(228)       Save
    Objective To study the increasing use of sports and fitness APPs against the background of national fitness and post-epidemic era, and to provide some suggestions for the development of sports and fitness APPs. Methods Literature survey and mathematical statistics were used to define the concept of sports and fitness APPs, and their characteristics and advantages were investigated. Then, their problems were pointed out. Results and Conclusion The existing problems include some APPs favoring female users, single function, and slightly backward profit model. Some countermeasures such as enriching course types, taking into account all categories of users, expanding more functions, improving service quality, broadening profit channels, and improving marketing level are put forward. This can provide theoretical basis for the operation of sports and fitness APPs and better popularize the culture of national fitness.
    Related Articles | Metrics | Comments0
    An Exploration of Improving the Regulatory System for Online Pharmacy Based on New Policy
    Xu Jialin, Wang Shuling, Liu Jingshuo
    Asian Journal of Social Pharmacy    2025, 20 (1): 20-27.  
    Abstract141)      PDF(pc) (361KB)(114)       Save
    Objective To analyze the current situation of drug regulation after introducing the new policy for China’s online pharmacy, and to provide reference for the regulation of online pharmacy based on the international experience. Methods Through literature research and comparative analysis, the history of policies for online pharmacy in China was investigated, and the current situation and problems of regulation for online pharmacy were explored. Results and Conclusion It is found that the body, basis and behavior of online prescription drug supervision in China should be improved. Combining experience in regulating online prescription drug at home and abroad, we provide some suggestions for the implementation of China’s online prescription drug policy by establishing a government-led multiple regulatory mechanism, standardizing the access qualifications for enterprises with business in online prescription drugs, improving the prescription inquiry and review system, and paying attention to consumer needs.
    Related Articles | Metrics | Comments0
    Research on the Optimization of China’s Pharmacovigilance Organization Management
    Zhang Zhi, Sun Lihua
    Asian Journal of Social Pharmacy    2025, 20 (1): 10-19.  
    Abstract133)      PDF(pc) (3365KB)(112)       Save
    Objective To analyze the problems of China’s pharmacovigilance organization system, and to provide targeted suggestions for improving it. Methods The relevant literature at home and abroad was reviewed to compared the differences in pharmacovigilance organizations in the United States, the European Union, Japan and China. Then, the problems of China’s pharmacovigilance organization management were found out. Results and Conclusion China’s pharmacovigilance organizational system has problems such as inadequate organizational setup, immature institutional construction, no coordination mechanism for pharmacovigilance practice, and industry associations of third-party organizations having no role to play. It is recommended to carry out theoretical and methodological research on the pharmacovigilance organizational system to provide practical guidance for optimizing the system with Chinese characteristics.
    Related Articles | Metrics | Comments0
    Rapid Health Technology Evaluation of Off-label Use of Magnesium Isoglycyrrhizinate Injection
    Yao Lan, Li Lin, Tian Lijuan
    Asian Journal of Social Pharmacy    2025, 20 (1): 80-87.  
    Abstract121)      PDF(pc) (429KB)(1012)       Save
    Objective To evaluate the preventive drug use of magnesium isoglycyrrhizinate injection beyond the instructions by rapid health technology, and to provide reference for its rational clinical application. Methods The databases such as PubMed, Embase, the Cochrane Library, HowNet, Wanfang, VIP and HTA websites were searched. Two researchers screened the literature to extract data according to the inclusion and exclusion criteria. If necessary, a third researcher was consulted. The included literature was analyzed and concluded through corresponding quality evaluation. Results and Conclusion Four meta-analysis articles and five pharmacoeconomics articles were included. In terms of effectiveness, compared with the blank group and the control group (diammonium glycyrrhizinate, glutathione, and polyene phosphatidylcholine), the preventive use of magnesium isoglycyrrhizinate injection had a lower incidence of drug-induced liver injury with a more significant reduction in the levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and total bilirubin. In terms of safety, except for an economic study in which some patients had a transient increase in blood pressure during the use of magnesium isoglycyrrhizinate injection, other studies did not show the increasing risk of adverse reactions due to preventive medication. In terms of economy, the use of magnesium isoglycyrrhizinate injection for prevention of different diseases did not necessarily have economic advantages over the control group (blank group and reduced glutathione, polyene phosphatidylcholine injection, traditional Chinese medicine combined with magnesium isoglycyrrhizinate injection). In the prevention of drug induced liver injury, magnesium isoglycyrrhizinate injection used beyond the instructions has certain efficacy and safety, but it may not be the economic optimal for other different diseases.
    Related Articles | Metrics | Comments0
    Identification and Prediction of Key Technologies in Ginsenosides Based on Genetic Knowledge Persistence Algorithm
    Li Qian, Zhang Wenfeng, Yuan Hongmei
    Asian Journal of Social Pharmacy    2025, 20 (1): 68-79.  
    Abstract120)      PDF(pc) (1101KB)(80)       Save
    Objective To study the key technologies in the field of ginsenosides and to offer a guide for the future development ginsenosides through the main path identification method based on genetic knowledge persistence algorithm (GKPA). Methods The global ginsenoside invention authorized patents were used as the data source to construct a ginsenoside patent self-citation network, and to identify high knowledge persistent patents (HKPP) of ginsenoside technology based on the GKPA, and extract its high knowledge persistence main path (HKPMP). Finally, the genetic forward and backward path (GFBP) was used to search the nodes on the main path, and draw the genetic forward and backward main path (GFBMP) of ginsenoside technology. Results and Conclusion The algorithm was applied to the field of ginsenosides. The research results show the milestone patents in ginsenosides technology and the main evolution process of three key technologies, which points out the future direction for the technological development of ginsenosides. The results obtained by this algorithm are more interpretable, comprehensive and scientific.
    Related Articles | Metrics | Comments0
    Research on the Optimization of the Registration Classification of Biological Products in China
    Li Zhiyi, Huang Zhe
    Asian Journal of Social Pharmacy    2025, 20 (2): 99-105.  
    Abstract118)      PDF(pc) (842KB)(634)       Save
    Objective To provide a theoretical basis for the adjustment of the registration classification of China’s biological products, and to establish a continuously improved registration classification system. Methods Based on literature research, the specific classification methods, classification principles and considerations of biological registration in China, the United States and the European Union were studied to form a complete comparative analysis. Results and Conclusion It is recommended that the division between therapeutic and preventive use should be removed from the registration classification of biologics. The therapeutic, preventive and diagnostic use of the product should be limited as part of the product specification, and the registration should be classified according to the development of biotechnology, innovation, modification and bio-similar drugs. In addition, the supervision of registration of advanced therapeutic products should be different from that of traditional biologics.
    Related Articles | Metrics | Comments0
    Research on Coordination Model of Pharmaceutical Supply Chain under Carbon Emission Trading Policy
    Zhang Minghe, Huang Zhe
    Asian Journal of Social Pharmacy    2025, 20 (3): 199-211.  
    Abstract113)      PDF(pc) (6028KB)(137)       Save
    Objective To provide effective decision making for the subsidy policies given by the government to pharmaceutical enterprises and the coordination model adopted by pharmaceutical stakeholders under the carbon emission trading policy. Methods The Stackelberg model was used to discuss the optimal profits of each member and the whole supply chain under different decision-making models while considering the technical capacity of emission reduction and cost sharing contract. Based on this, the impact of the combined contract decisionmaking model on the technical efforts of drug manufacturers to reduce carbon emission, the profits of supply chain members and the overall profits of supply chain was investigated. Results and Conclusion Research has found that improving the research and development efforts of emission reduction technologies by pharmaceutical enterprises can increase drug sales and enhance the expected profits of pharmaceutical supply chain members. The members of the secondary pharmaceutical supply chain can achieve the optimal expected profit when reaching cooperation. Besides, when the cost sharing contract and quantity discount contract meet the constraint conditions, the combined contract decision model can perfectly coordinate the pharmaceutical supply chain, enabling supply chain members to achieve Pareto improvement and gradually reach Pareto optimum.
    Related Articles | Metrics | Comments0
    Study on the Market Environment of Heparin and Development Suggestions in China Based on the PEST Model
    Han Chengcheng, Dong Li
    Asian Journal of Social Pharmacy    2025, 20 (1): 38-46.  
    Abstract105)      PDF(pc) (393KB)(646)       Save
    Objective To analyze the market environment of heparin, and to provide reference for the development of the heparin industry in China. Methods The international market size and competition pattern of heparin was investigated first. Then, environmental analysis of it was made based on the PEST model. Results and Conclusion There is room for optimization of the relevant policies for the development of heparin industry in China. The use of heparin drugs and regulation should be further improved. In addition, the research and development ability of pharmaceutical enterprises should be enhanced, and the development strategy of heparin industry needs to be adjusted.
    Related Articles | Metrics | Comments0
    Research on the Relationship between Government R&D Subsidies of Different Sub-industries in China’s Pharmaceutical Industry and Enterprises’ R&D Investment
    Wang Xinke, Chang Senhao, Chen Yuwen
    Asian Journal of Social Pharmacy    2025, 20 (1): 47-56.  
    Abstract103)      PDF(pc) (432KB)(96)       Save
    Objective To empirically analyze the relationship between Government R&D funding and R&D investment of the enterprises in different sub industries of pharmaceutical industry, and to provide reference for the development of policies related to R&D funding input. Methods Granger causality test was performed using the data of relevant indicators in different sub industries of China’s pharmaceutical industry from 1995 to 2019 based on the theory of covariance. Results and Conclusion The funding of R&D from the government had a significant positive effect on their R&D funding inputs to enterprises with chemo products, Chinese patent products, and biological products. It means the improvement of government funding was beneficial in promoting the R&D investment from various sub industries of pharmaceutical industry. The order of this influence was biological products, chemo products, and Chinese patent drugs. As to chemical drugs and biological products, the government’s R&D funding and enterprises R&D funding input showed a good trend of mutual promotion in a certain lag period. The government can fully leverage its funding to promote the investment of all sub industries of pharmaceutical industry. Meanwhile, regulatory mechanisms should be refined for government funding. For the inheritance, innovation, and development of traditional Chinese medicine, the government should give more policy support than financial support.
    Related Articles | Metrics | Comments0
    Comparison and Suggestions on the Registration and Regulation of Biosimilars between China and the USA
    Cao Yizhi, Lian Guiyu
    Asian Journal of Social Pharmacy    2025, 20 (1): 28-37.  
    Abstract102)      PDF(pc) (610KB)(116)       Save
    Objective To put forward some suggestions for improving the registration and regulation, the efficiency of evaluation, and approval of biosimilar in China so as to promote the development of biopharmaceutical industry and increase the accessibility of therapeutic drugs in China. Methods Literature related to the registration and regulation, evaluation and approval of biosimilars were sorted out to analyze the differences in China and the USA. Results and Conclusion Based on the analysis of the current situation of registration and regulation of biosimilars between China and the USA, it is suggested to improve the registration and regulation of biosimilars in China from the following four aspects: Establishing a biosimilar regulatory department, expanding the professional evaluation personnel, scientifically simplifying the registration and approval procedures, and constantly refining the types of communication meetings.
    Related Articles | Metrics | Comments0
    Quantitative Analysis of the Policy of Centralized Drug Procurement Based on PMC Index Model
    Duan Xiaoxiang, Wang Shuling
    Asian Journal of Social Pharmacy    2025, 20 (3): 222-235.  
    Abstract95)      PDF(pc) (6829KB)(1178)       Save
    Objective To quantitatively analyze the policy of centralized drug procurement centralized drug procurement in order to provide reference for the subsequent policy formulation and improvement. Methods Text mining method was used to process 15 centralized drugs procurement policies issued at the national level during 2015-2022, and a PMC index evaluation model of centralized drug procurement policies was established. Then, 15 centralized drug procurement policies were quantitatively analyzed from the overall and comparative perspective through an evaluation model. Results and Conclusion The average PMC index of 15 centralized drug procurement policies was 6.95, which was acceptable on the whole. Among them, eight were excellent and seven were acceptable. As to the first-order variables, the centralized drugs procurement policy still lacks incentives and constraints. The comparative results show that there are differences in the content and structure of policies, but they are strongly related to each other. Chinese centralized drug procurement policy has been basically formed, which is closely related to medical insurance and medical policies. However, it is still necessary to pay attention to the structure of the policy to ensure the elaboration of the policy content.
    Related Articles | Metrics | Comments0
    Study on the Impact of Digital Economy on Innovation of Pharmaceutical Companies
    Li Jingran, Zhang Dawei, Jia Zheng, Xing Hua
    Asian Journal of Social Pharmacy    2025, 20 (1): 57-67.  
    Abstract91)      PDF(pc) (627KB)(295)       Save
    Objective To study the importance of digital economy to promote the innovation development of enterprises under the background of the era of information technology reform. Methods The maximum entropy method was used to measure the comprehensive level of digital economy development at provincial level. Besides, the impact of digital economy on the innovation performance of pharmaceutical industry was investigated empirically by using A-share pharmaceutical companies listed in China from 2013 to 2020 as a research sample, and the mediating mechanism of R&D investment and financing constraints on the impact was examined. Results and Conclusion It is found that digital economy is significantly and positively related to the innovation performance of enterprises. The mechanism test shows that digital economy improves innovation performance through the expansion effect of R&D investment and alleviating financing constraints. In the context that digital economy has become a new driving force for enterprise innovation, the combination of digital economy and real economy should be actively promoted, R&D investment in pharmaceutical enterprises should be increased, and financing channels should be broadened.
    Related Articles | Metrics | Comments0
    Literature Analysis of Adverse Effects Induced by Sunitinib
    Lv Mengru, Tian Lijuan
    Asian Journal of Social Pharmacy    2025, 20 (3): 212-221.  
    Abstract86)      PDF(pc) (1116KB)(70)       Save
    Objective To analyze adverse drug reactions (ADR) caused by sunitinib and provide reference for clinical safety. Methods The case reports of ADR related to sunitinib in six Chinese and English databases from 2006 to 2021 were searched to extract relevant data, and then statistical analysis was performed. Results and Conclusion A total of 147 articles were included, involving 156 cases and 283 adverse events. Adverse reactions occurred at the highest rate after 31 to 180 days of drug administration, and ADR involved organs/systems mainly in blood and lymphatic disorders (17.67%), gastrointestinal disorders (15.55%), and skin and subcutaneous tissue disorders (10.60%). The adverse effects caused by sunitinib involve multiple organs/systems throughout the body. Besides, there are many severe fatal cases. During clinical medication, patients should be monitored regularly, and drugs should be reduced or stopped timely when adverse reactions occur to reduce the risk of clinical medication.
    Related Articles | Metrics | Comments0
    Exploring the Inheritance and Innovation of Traditional Chinese Medicine from the Perspective of Registration
    Zhu Juncheng, Wang Shuling
    Asian Journal of Social Pharmacy    2025, 20 (2): 106-115.  
    Abstract85)      PDF(pc) (2622KB)(113)       Save
    Objective To study the inheritance and innovation of traditional Chinese medicine, and to offer an insight for the public. Methods Literature review, data retrieval and systematic analysis were used to elaborate and summarize the influence of changes in related classification and policy reform of traditional Chinese medicine (TCM) registration on its inheritance and innovation. The study was carried out in the context of the TCM registration related classification and policy reform and evolution on TCM inheritance and innovation. Results and Conclusion TCM registration plays an important role in the inheritance and innovation of TCM, which greatly influences on its inheritance and innovation. The reform of new registration classification respects the law of TCM research and development, reflecting the establishment of the review and approval system in line with the characteristics of TCM inheritance, which promotes the research and development of new drugs. The establishment of the review and approval system also accelerates the marketing transformation of new traditional Chinese medicine. TCM innovation should attach importance to clinical value orientation and improve the scientific connotation of TCM. Meanwhile, the advantage of China’s accession to ICH, PIC/S and other international drug certification organizations should be taken to speed up the construction of international mutual recognition of TCM standardization system, which can provide a broader path for the inheritance and innovation of TCM in the new era.
    Related Articles | Metrics | Comments0
    Quality Risk Management of the Changes of Sponsors and Production Sites of Drug Clinical Trial - Taking FDA’s Management as Reference
    Yu Bing, Chen Zhen, Wu Zhiang, Yang Jianghong
    Asian Journal of Social Pharmacy    2025, 20 (2): 146-157.  
    Abstract70)      PDF(pc) (2668KB)(104)       Save
    Objective To explore the risk management of the changes of sponsors and/or production sites during drug clinical trials based on the theories of quality management, risk management, and change management. Methods The method of failure modes and effect analysis (FMEA) was used to identify risks through literature research, expert consultation, comparative research, and comprehensive analysis. Besides, risk priority number (RPN) was used to evaluate the risks. Results and Conclusion A FMEA of the changes of sponsors and/or production sites in clinical trials was constructed and RPN values of every failure mode and causes were obtained. Based on the RPN values, the core risk control points for different combination modes of sponsors and/or production sites after their changes were identified. It is recommended that China should strengthen the construction of the sponsor responsibility system. In addition, the changes of sponsors and/or production sites during the clinical trial period should be allowed in an orderly manner under the premise of ensuring the quality of clinical trials and subject protection.
    Related Articles | Metrics | Comments0
    A Dual-Perspective Study on the Impact of Mergers and Acquisitions Companies on their Innovation Performance - Taking Company J as an Example
    Dong Li, Li He
    Asian Journal of Social Pharmacy    2025, 20 (2): 165-174.  
    Abstract68)      PDF(pc) (2714KB)(57)       Save
    Objective To explore the impact of mergers and acquisitions (M&A) on the innovation performance of the companies from both a patent perspective and a financial perspective by taking the case of M&A Company J as an example. Methods The literature research method, patent data analysis method, and financial data analysis method were used. Results and Conclusion The M&A has a positive impact on the innovation performance of Company J, and the results from the patent perspective and the financial perspective are consistent. The literature research method, patent data analysis method, and financial data analysis method were used. The M&A has a positive impact on the innovation performance of Company J, and the results from the patent perspective and the financial perspective are consistent.
    Related Articles | Metrics | Comments0
    Construction of Clinical Evaluation Index System of National Generic Drugs Centralized Bidding Procurement
    Qiu Qingqing, Yan Wei, Xu Dongyan, Fu Shuyong, Jia Zheng, Xing Hua
    Asian Journal of Social Pharmacy    2025, 20 (3): 245-255.  
    Abstract68)      PDF(pc) (3645KB)(31)       Save
    Objective To establish a scientific, reliable, objective, and effective clinical comprehensive evaluation system for drugs centralized bidding procurement by government, and to conduct reliability and validity test and empirical analysis of the evaluation index system through simulated measurement. Methods Literature research method was used to select comprehensive evaluation indicators for drugs centralized bidding procurement. Then, Dephi method was applied to screen the final evaluation indicators, and the weight of the indicators was determined using analytic hierarchy process. Results and Conclusion The final clinical efficacy evaluation index system for drugs centralized bidding procurement includes 5 primary indicators and 13 secondary indicators. The experts authority coefficient in this study is high, and their opinions relatively coincide. Through the empirical research, the reliability and structural validity of the indicator system is good. This indicator system enriches methods and tools for scientifically evaluating the clinical efficacy of drugs centralized bidding procurement.
    Related Articles | Metrics | Comments0
    Design of the Quality System for Pharmaceutical Commissioned Production under MAH System
    Yu Chunyan, Chen Yuwen
    Asian Journal of Social Pharmacy    2025, 20 (3): 256-266.  
    Abstract67)      PDF(pc) (838KB)(38)       Save
    Objective To ensure the quality and safety of drugs in the whole cycle of pharmaceutical commissioned production under the drug marketing authorization holder (MAH) system, and to establish a perfect quality management system for it. Methods Literature review was used to study the factors that influenced the quality management system of pharmaceutical commissioned production because the implementation of MAH system in China was late, and the experience accumulated by pharmaceutical industry was not enough. Results and Conclusion Based on the MAH system, it is of great significance to establish the quality management system for pharmaceutical commissioned production.
    Related Articles | Metrics | Comments0
    Relationship between R&D Investment and Enterprise Performance of Pharmaceutical Enterprises in China: Research on 45 Domestic Listed Pharmaceutical Companies Based on Panel Data
    Fu Shuyong, Chen Shuyu, Zhang Qing
    Asian Journal of Social Pharmacy    2025, 20 (2): 175-183.  
    Abstract64)      PDF(pc) (882KB)(66)       Save
    Objective To study the causal relationship between R&D investment and enterprise performance of domestic pharmaceutical enterprises. Methods Panel data model was adopted for empirical analysis. Results and Conclusion Increasing the R&D investment intensity of pharmaceutical enterprises in the Yangtze River Delta and Zhejiang by 1% will increase their profit margins by 0.79% and 0.46%. On the contrary, if the profit margin increases by 1%, the R&D investment intensity will increase by 0.25% and 0.19%. If the profit margin of pharmaceutical enterprises in Beijing, Tianjin, Hebei, Chengdu, Chongqing and other regions increases by 1%, the R&D investment intensity will increase by 0.14%, 0.07% and 0.1%, respectively, which are lower than those in the Yangtze River Delta and Zhejiang. The relationship between R&D investment and enterprise performance of pharmaceutical enterprises in the Yangtze River Delta and Zhejiang Province is Granger causality, showing a two-way positive effect. Profits and R&D investment of pharmaceutical enterprises in Beijing, Tianjin, Hebei, Chengdu, Chongqing and other regions are also Granger causality. But in the Pearl River Delta, profits and R&D investment have not passed the stability test, it is impossible to determine the causality between them.
    Related Articles | Metrics | Comments0
    Research on the Optimization of Pharmacovigilance Laws and Regulations in China
    Zhang Zhi, Zhang Linlin, Feng Yuguo, Huang Jiaxin, Wang Huiyan, Sun Lihua
    Asian Journal of Social Pharmacy    2025, 20 (2): 116-125.  
    Abstract62)      PDF(pc) (907KB)(80)       Save
    Objective To analyze the problems of China’s pharmacovigilance legislation, and to provide some suggestions for improving it. Methods Relevant literature at home and abroad were studied to compare the laws and regulations of the United States, the European Union, Japan and China. Then, the problems of China’s pharmacovigilance legislation were analyzed. Results and Conclusion The Chinese pharmacovigilance legislation has such problems as nontransparent formulation process, poor dynamic adaptability, insufficient use of the attention mechanism, fragmentation of laws and regulations, and poor connection of laws and regulations, which should be optimized. It is recommended to carry out theoretical and methodological research on pharmacovigilance legislation to provide practical guidance for optimizing pharmacovigilance legislation with Chinese characteristics.
    Related Articles | Metrics | Comments0
    Establishing New Mechanisms for Public-Private Partnerships to Address Common Challenges in Drug R&D
    Dong Lijuan, Sun Lihua
    Asian Journal of Social Pharmacy    2025, 20 (2): 158-164.  
    Abstract61)      PDF(pc) (946KB)(55)       Save
    Objective To study the cases of public-private partnerships (PPPs) commonly used in Europe Union and the United States to solve common challenges such as the decline in drug R&D efficiency, and to provide reference for developing countries to deal with these challenges in drug R&D. Methods Multiple case study method was used to make a comparative analysis of three PPP models in European Union and the United States. Results and Conclusion Third-party conveners, project-based cooperation models, and PPP funding mechanisms were key elements of PPP models in European and the United States. The developing countries should establish new PPP mechanisms to solve common challenges in drug R&D in their countries based on national conditions and key elements of PPP models.
    Related Articles | Metrics | Comments0
    The Current Development of Internet Pharmacy Services in China
    Zhao Xuanhe, Xiu Yu, Wang Shuling
    Asian Journal of Social Pharmacy    2025, 20 (3): 298-308.  
    Abstract61)      PDF(pc) (2093KB)(35)       Save
    Objective To study the current situation and corresponding characteristics of internet pharmacy services and summarize their core connotations, and to make some suggestions for their future development based on national policies. Methods The literature of the last 20 years that fully or partially matched the theme of internet pharmacy services in China was studied to summarize the status of research and development of remote pharmacy services by combining the web survey method. Results and Conclusion China’s internet pharmacy services include online consultation, science education, information enquiry, follow-up and intervention, and other functions. The main service providers are medical institutions, Internet enterprises, and online drug sales platforms. Internet pharmacy services can improve patients’ compliance with medication and the convenience of medical treatment, which better play the role of pharmacists. However, they also face problems such as the varying service qualities, the small number of users, the difficulty in popularizing services in remote areas, and the lack of supervision and protection of patients’ rights.
    Related Articles | Metrics | Comments0
    A Cost-Effectiveness Analysis of Magnetic Resonance Imaging Contrast Agent for Early Diagnosis of Hepatocellular Carcinoma Based on Decision Tree + Partitioned Survival Model
    Shang Yumeng, Zhang Fang, Dong Li
    Asian Journal of Social Pharmacy    2025, 20 (2): 184-194.  
    Abstract60)      PDF(pc) (3113KB)(81)       Save
    Objective To evaluate the cost-effectiveness of gadopentetate dimeglumine (Gd-DTPA) and gadobenate dimeglumine (Gd-BOPTA) magnetic resonance imaging (MRI) contrast agents for the early diagnosis of hepatocellular carcinoma (HCC) from the perspective of China’s healthcare system. Methods A decision tree + partitioned survival model was constructed for early diagnosis of HCC based on literature data. Taking qualityadjusted life year (QALY) as the main health outcome measure for incremental cost-effectiveness ratio (ICER) analysis, the sensitivity analysis by Monte Carlo simulation was constructed to generate corresponding tornado diagram, incremental cost-effectiveness scatter plot, and cost-effectiveness acceptability curve. Results and Conclusion The basic analysis results showed that the ICER value of Gd-BOPTA diagnostic scheme compared with Gd-DTPA diagnostic scheme was 17 302.46 yuan/QALY, which is less than 1 times of China’s gross domestic product (GDP) per capita. The sensitivity analysis results showed that the cost of delayed treatment and timely treatment had a significant impact on the results. When the willingness to pay (WTP) was 1 time of GDP per capita, the probability of cost-effectiveness advantage of Gd-BOPTA diagnostic scheme was 65.30%. When the WTP value is set at 1 times of GDP per capita, Gd-BOPTA MRI has cost-effectiveness advantages for the early diagnosis of HCC.
    Related Articles | Metrics | Comments0
    Quality Evaluation and Problem Analysis of China’s Pharmacoeconomics on Hypertension Management
    Liu Xinying, Sun Lihua, Zhu Tianyu, Chen Ping
    Asian Journal of Social Pharmacy    2025, 20 (3): 267-275.  
    Abstract56)      PDF(pc) (2671KB)(78)       Save
    Objective To systematically evaluate the quality of pharmacoeconomics on hypertension management, and provide reference for promoting the development of pharmacoeconomics in China. Methods Some Chinese databases including CNKI, VIP, Wanfang, as well as international databases such as PubMed and Web of Science were searched to collect studies of economic evaluation on hypertension management in China. The quality of health economic studies (QHES) scale was used to assess the quality of the literature and to analyze the current situation and shortcomings of pharmacoeconomics in the field of hypertension in China. Results and Conclusion A total of 363 articles were included in this study. The quality assessment results showed that the average score of pharmacoeconomics on hypertension management was 42.54 points. The quality of literature published by medical institutions was significantly lower than that published by universities/research institutes (41.25 vs. 54.68, P < 0.05). Among the 363 articles, 3.31% (12 articles) were of high quality (75-100 points), 29.20% (106 articles) were of moderate quality (50-74 points), 66.12% (240 articles) were of low quality (25-49 points), and 1.38% (5 articles) were of extremely low quality (0-24 points). These papers have such problems as unclear research perspectives, single research methods, ambiguous data sources, inappropriate study duration for disease characteristics, and insufficient sensitivity analysis factors. Overall, the quality evaluation of pharmacoeconomics on hypertension management in China is generally low with poor standardization, which should be improved in the future.
    Related Articles | Metrics | Comments0
    Visual Analysis of the Research Status of Active Surveillance of Drug Safety in China Based on CiteSpace
    Xue Yisong, Chang Ping, Xing Hua
    Asian Journal of Social Pharmacy    2025, 20 (2): 134-145.  
    Abstract54)      PDF(pc) (4978KB)(57)       Save
    Objective To analyze the current research status and development trend of active surveillance of drug safety in China, and to provide reference and suggestions for future research. Methods Using bibliometric methods and with the help of the CiteSpace 6.1.R6, the literature on active surveillance of drug safety in CNKI from 2010 to 2022 was visualized and analyzed in terms of authors, institutions and keywords. Results and Conclusion The research on active surveillance of drug safety in China started late and is in a stable development period. Some Chinese scholars have done more work on active surveillance of drug safety. Additionally, a number of institutions have published some articles and surveillance objects, surveillance methods, and surveillance results are the main research content. However, the cross-institutional cooperation is not close. The traditional Chinese medicine injection, centralized surveillance, and automatic surveillance are the hot spots of research. It is the latest research frontier to use the Chinese hospital pharmacovigilance system to actively monitor drug safety. At present, the research related to active surveillance of drug safety in China is still in the early stage, and more in-depth research is needed to follow up.
    Related Articles | Metrics | Comments0
    Research and Inspiration of Drug Traceability System in the USA
    Zhang Qi, Tian Lijuan
    Asian Journal of Social Pharmacy    2025, 20 (3): 236-244.  
    Abstract52)      PDF(pc) (4650KB)(40)       Save
    Objective To draw on the experience of the construction and development of drug traceability system in the USA and to provide reference for improving China’s drug traceability system. Methods Literature research and comparative study were used to sort out the background and development of drug traceability system in the USA, including drug traceability code, drug traceability model, drug traceability platform and the application of blockchain technology. On this basis, some suggestions on the construction of drug traceability system in China were put forward. Results and Conclusion The United States has a perfect system of laws and regulations on drug traceability, which encourages the construction of third-party traceability platforms to avoid the formation of monopolies. Besides, the application of blockchain technology in the construction of drug traceability system is also relatively mature. It is suggested that China strengthen the construction of drug traceability system, give play to the advantages of third-party traceability platforms, and improve the application of blockchain technology in drug traceability.
    Related Articles | Metrics | Comments0
    Brief Discussion on the Enlightenment of FDA’s Comparability Protocol to the Post-Approval Change Management of New Drugs in China
    Lu Xiaoling, Tian Lijuan
    Asian Journal of Social Pharmacy    2025, 20 (2): 126-133.  
    Abstract52)      PDF(pc) (2300KB)(75)       Save
    Objective To discuss the flexible supervision and communication mode in the post-approval change (PAC) of drugs, to explore how to ensure the quality and availability of drugs during the changes, and to provide some suggestions and reference for promoting the timely marketing of drugs. Methods Based on the comparability protocol guidelines issued by the US FDA in October 2022, the regulatory status quo of PAC between China and the US was compared to explore the feasibility of implementing comparability protocols in China. Results and Conclusion According to the specific situation of post-approval of drug change supervision, some suggestions were put forward to optimize the PAC management procedure, such as establishing the communication pathways between holders and health authorities, publishing relevant guidance and strengthening training, so as to provide reference for the implementation of comparability protocols in China.
    Related Articles | Metrics | Comments0
    Evaluation of Clinical Value of Siltuximab in Castleman Disease Based on Multi-criteria Decision-making
    Li Jiaxun, Guo Xiaoming, Zhang Fang, Dong Li
    Asian Journal of Social Pharmacy    2025, 20 (3): 276-288.  
    Abstract51)      PDF(pc) (2464KB)(170)       Save
    Objective To evaluate the clinical value of siltuximab in the treatment of Castleman disease based on multicriteria decision analysis (MCDA) and evidence and value: Impact on decision making (EVIDEM) framework. Methods The evidence matrix for quantitative analysis of MCDA was extracted through literature research, and the weight of each evaluation index was calculated by the maximum differentiation measure in conjoint analysis. Besides, the clinical value of siltuximab in the treatment of Castleman disease was analyzed quantitatively and qualitatively based on the results of expert questionnaire surveys. Results and Conclusion The clinical value score of siltuximab was 0.491, and the weight ratio of “therapeutic benefit” (15.39%), “drug effectiveness” (14.46%) and “drug safety” (11.43%) were the three largest. Among the indexes of “drug effectiveness” “drug safety” “patient reported outcome” “therapeutic benefit” and “non-medical cost”, siltuximab for Castleman disease was considered to be a more valuable treatment option than other first-line therapies. By qualitative analysis, 57% experts believed that siltuximab was a better treatment option. The indexes that contribute the most to the overall clinical value of siltuximab are “ therapeutic benefit” “drug effectiveness” and “quality of evidence”, while the indexes that have a negative impact on the clinical value of siltuximab is “drug treatment cost”.
    Related Articles | Metrics | Comments0
    Research on Biopharmaceutical Innovation in Africa Based on Patent Information
    Oluka Longinus Obinna, Yuan Hongmei
    Asian Journal of Social Pharmacy    2025, 20 (3): 289-297.  
    Abstract48)      PDF(pc) (2244KB)(46)       Save
    Objective To explore the current state of biopharmaceutical innovation in Africa by analyzing patent data related to biopharmaceutical products in African countries. Methods Based on patent data, simple descriptive statistical methods were used to analyze the trend of patent applications, the geographical distribution of patents, and the distribution of applicants in the pharmaceutical field in Africa. Besides, Excel software was used to draw charts to visualize statistical information. Results and Conclusion According to the result, a large number of patents has been granted in these countries and the number is steadily rising each year. From the figure below, we can see that the largest number of patents was granted to Morocco in 2014 with a total number of 613 patents followed by Tunisia with 315 patents, the African Intellectual Property Organization (OAPI) with 124 patents, South Africa with 106 and Mozambique with 1 patent based on data availability (IncoPat Global Patent Search Database). It was observed that, as patents were granted, the number of applications filed on this continent increased. The largest number of patents has been recorded by Morocco, Tunisia and South Africa. Patent applications in Morocco increased fast with an average annual growth of 7.3%. The increase in patent applications is due to improved research infrastructure and enhanced research activities, which shows the importance of biopharmaceutical innovation in the continent.
    Related Articles | Metrics | Comments0
    Construction of Evaluation Index System for the Policy Effect of Centralized Drug Procurement
    Huang Jiaxin, Raela·Abduhilil, Hu Ping, Liu Xinying, Sun Lihua
    Asian Journal of Social Pharmacy    2025, 20 (4): 313-324.  
    Abstract41)      PDF(pc) (2719KB)(47)       Save
    Objective To construct an index system for evaluating the policy effect of centralized drug procurement, and to provide reference for comprehensively and systematically evaluating the policy of centralized drug procurement. Methods Through combing the policies and literature research, the focus and expected goal of China’s centralized drug procurement policy were clarified. On the basis of policy concerns, combined with some theories and the implementation of drug centralized procurement policy, a primary evaluation index system was constructed. The index system was determined by expert consultation, and the weight of each index was calculated by analytic hierarchy process. Results and Conclusion The questionnaire recovery rates of the two rounds of expert consultation were 88.23% and 100%, the coefficients of authority of experts were 0.86 and 0.80, and the expert coordination coefficients were 0.338 and 0.294, respectively. Finally, the evaluation index system for the policy of centralized drug procurement was established, which included 4 first-level indicators, 10 second-level indicators and 23 third-level indicators. The evaluation index system constructed in this paper can not only make up for the deficiency of systematic evaluation of the policy effect of the current centralized drug procurement, but also provide reference for further improving this policy.
    Related Articles | Metrics | Comments0
    A Comparison of Pediatric Drug Policy and Development in China and the United States
    Zhao Xinran, Munire Mohetaer, Sun Xiaowen, Wang Su, Chen Yuwen
    Asian Journal of Social Pharmacy    2025, 20 (4): 325-336.  
    Abstract30)      PDF(pc) (910KB)(23)       Save
    Objective To find the shortcomings of children’s drug research and development policy in China, and to put forward feasible suggestions for encouraging China’s children’s drug research and development by drawing the experience from the United States. Methods To compare the similarities and differences between the policies guiding the use of children’s medicines issued by China and the United States. Results and Conclusion In recent years, the Chinese government has introduced a number of policies, but there is still a big gap in clinical trial design and drug review system compared with the policies of the United States. China should further improve the laws and regulations related to children’s medication, promote the development of clinical trials, develop pricing programs, and expand international cooperation, so as to formulate more scientific and comprehensive guiding principles for the research and development of children’s medication.
    Related Articles | Metrics | Comments0
    Research on Incentive Mechanism of Repurposing Drugs for Rare Diseases
    Wu Xiaoling, Yuan Hongmei
    Asian Journal of Social Pharmacy    2025, 20 (4): 337-344.  
    Abstract25)      PDF(pc) (897KB)(22)       Save
    Objective To improve the system of accelerated review and approval, and to speed up the development and marketing of repurposing drugs for rare diseases in China. Methods The relevant concepts of rare diseases and the definition of drug repurposing were introduced so as to sort out the advantages and disadvantages of the research and development of drug repurposing for rare diseases. Then, the incentive mechanisms of the research and development of drug repurposing for rare diseases in China and abroad were compared. Results and Conclusion Some suggestions on improving the incentive mechanism of repurposing drugs for rare diseases such as policy support for talents introduction, capital investment, and innovation capabilities are proposed. Besides, the government should further improve policies for the research and development of repurposing drugs for rare diseases, which can gradually narrow the gap between the research and innovation of drug repurposing in developed countries, thus benefiting the patients of rare diseases.
    Related Articles | Metrics | Comments0
    Thoughts on the Construction of Pediatric Exclusivity Policy in China
    Zhang Ke, Tian Lijuan
    Asian Journal of Social Pharmacy    2025, 20 (4): 345-354.  
    Abstract22)      PDF(pc) (1997KB)(21)       Save
    Objective To study the 6-month patent exclusivity rule in the US and provide reference for designing pediatric exclusivity policy in China. Methods In this paper, summarize the development history and status of pediatric exclusivity in the US was summarized to analyze its effect for pediatric drugs research and development incentive and information improvement. Then, we can learn from its experience to construct pediatric exclusivity policy in China. Results and Conclusion Pediatric exclusivity policy in the US has obvious incentive effects, but the scope is limited to patented or other data protected drugs. Based on the successful experience of the United States, we can fully evaluate the impact of patents and other data protection policies on the exclusive marketing rights. In addition, we should conduct in-depth study on the applicable objects, authorization scope, protection mode and time limit of the pediatric exclusivity so that we can introduce supporting measures for China’s pediatric exclusivity as soon as possible.
    Related Articles | Metrics | Comments0
    Research and Enlightenment of FDA’s Digital Health Software Pre-Cert Program
    Chang Ping, Huang Zhe
    Asian Journal of Social Pharmacy    2025, 20 (4): 363-373.  
    Abstract22)      PDF(pc) (945KB)(17)       Save
    Objective To study the supervision experiences of the US digital health software pre-cert program, and to provide reference for the scientific supervision of digital health in China. Methods By reviewing domestic and international databases from PubMed, Web of Science, CNKI, and Wanfang, as well as FDA’s website, the innovative regulatory pathway of software pre-cert was investigated comprehensively. Then, This method was compared with the current regulatory actions in China so as to propose some suggestions for digital health regulation in line with our national conditions. Results and Conclusion FDA’s software pre-cert program emphasizes assessment at the organizational level and product level first, streamlines the pre-market review process, and relies on post-market evidence generated from real-world data and elements of excellence appraisal to strengthen post-market regulation of software as a medical device (SaMD). However, post-marketing data in China are difficult to obtain, so this method cannot be copied totally. Currently, we can explore the elements that must be reviewed for registration of medical device according to enlightenment of the program, reduce the burden on enterprises and regulatory agency. At the same time, the post-marketing regulatory system should be improved gradually, and experience in the whole life cycle management of medical device should be accumulated, which can make preparations for enhancing the ability of regulatory innovation.
    Related Articles | Metrics | Comments0
    A Quantitative Analysis of China’s Pharmacovigilance Policy Based on the PMC Index Model
    Yao Tingzhen, Wang Shuling
    Asian Journal of Social Pharmacy    2025, 20 (4): 387-401.  
    Abstract20)      PDF(pc) (11981KB)(17)       Save
    Objective To study the current situation of China’s pharmacovigilance system, and to provide some suggestions for the improvement of related policies. Methods A policy modeling consistency (PMC) index model of pharmacovigilance policy was constructed to quantitatively assess the samples of policies combining text mining. Then, the PMC surface was established to obtain the visualization results of China’s pharmacovigilance policy samples, and their shortcomings were clearly analyzed by comparison. Results and Conclusion Forty-one percent of China’s pharmacovigilance policies were rated as excellent, 54% as acceptable, and the overall evaluation was acceptable. But there is still some room for improvement. On the whole, there are problems of insufficient policy synergy, lack of policy incentives and constraints, and incomplete coverage of policy functions. It is recommended that China’s pharmacovigilance policy system should be optimized by strengthening policy coordination, increasing policy incentives and constraints, and guiding multi-subjects to participate in coordination. These findings and recommendations can provide operational ideas for the system of China’s pharmacovigilance policy.
    Related Articles | Metrics | Comments0
    Analysis of the Development Strategies of the Export of Chinese Active Pharmaceutical Ingredients
    Zhou Yinhao, Dong Li
    Asian Journal of Social Pharmacy    2025, 20 (4): 413-419.  
    Abstract18)      PDF(pc) (1507KB)(75)       Save
    Objective To study the competitive advantages of Chinese active pharmaceutical ingredients by analyzing the international market situation and competition pattern of active pharmaceutical ingredient (API). Methods Through the analysis of the competition pattern of global API market, the advantages and shortcomings of China’s APIs in the international market were found out, and some development strategies and suggestions were put forward. Results and Conclusion It is urgent for China API enterprises to adjust their industrial structure, improve their production process, and actively participate in international certification for more export.
    Related Articles | Metrics | Comments0
    Current Situation and Management of Drug Shortage in Some Western Countries and Its Enlightenment to China
    Dong Sixu, Lian guiyu
    Asian Journal of Social Pharmacy    2025, 20 (4): 355-362.  
    Abstract16)      PDF(pc) (769KB)(23)       Save
    Objective To analyze the current situation of drug shortage in some western countries and their management strategies, and to put forward feasible suggestions for drug shortage management in China. Methods The methods of literature research and comparative study were used to collect policy information and related data from official government websites and news websites, then, the current situation and management of drug shortage in some western countries were compared and studied to summarize their effective experience in dealing with drug shortage. Results and Conclusion The current situation and influencing factors of drug shortage in these western countries are different, but the management system established to deal with drug shortage is good, including the support of policies and regulations, the early warning of monitoring platform and the construction of organizational system. Drawing lessons from their experience, China should strengthen cooperation and consultation among stakeholders and rationally allocate powers and responsibilities. The transparency of drug shortage data disclosure should be increased. The important role of pharmacists should be played to strengthen the management. Further optimizing the drug shortage management system in China can ensure the safety of drug supply.
    Related Articles | Metrics | Comments0
    The Construction of Market Credit Supervision System for Pharmaceutical Enterprises in Liaoning Province
    Luan Lijie, Tian Lijuan
    Asian Journal of Social Pharmacy    2025, 20 (4): 374-386.  
    Abstract14)      PDF(pc) (831KB)(26)       Save
    Objective To study the construction of market credit supervision systems for pharmaceutical enterprises in Liaoning Province and to provide suggestions for improving the integrity awareness and production activities. Methods Based on the market credit supervision experience of National Medical Products Administration and some other provinces, the construction of supervision laws and regulations system for pharmaceutical enterprises in Liaoning Province was investigated from the perspectives of daily supervision and inspection, joint punishment of illegal acts, sampling results, information communication and publicity. Results and Conclusion In recent years, Liaoning Provincial Party Committee and the People’s Government of Liaoning Province has attached great importance to the construction of social credit system by issuing a series of local regulations and local government rules. However, the laws and regulations on the market credit supervision of pharmaceutical enterprises are not perfect, and there is a lack of legal documents such as the credit rating method. Besides, some regulatory documents are slightly outdated and they should be revised in time according to the development of the pharmaceutical industry. The Food and Drug Administration of Liaoning Province should promulgate some relevant laws and regulations on the market credit supervision of pharmaceutical enterprises as soon as possible. Firstly, Liaoning Drug Administration should formulate the “Measures for the Administration of Drug Safety Credit of Pharmaceutical Enterprises”, including the establishment of credit information management system, which can clarify the main responsibility of pharmaceutical enterprises and key personnel, and standardize drug advertising and advertising endorsement. Secondly, Liaoning Drug Administration should introduce the “Credit Rating Methods for Pharmaceutical Enterprises”, and divide the credit rating of pharmaceutical enterprises into four grades from high to low. Besides, differentiated credit supervision measures must be implemented. Finally, the Pharmaceutical Industry Association of Liaoning Province should issue the industry norms that regard drug quality as life so as to improve the integrity awareness of pharmaceutical enterprises and promote the production activities.
    Related Articles | Metrics | Comments0
    Systematic Review and Quality Appraisal of Literature on Economic Evaluation of Drugs for Type 2 Diabetes
    Raela·Abduhilil, Lu Siyu, Sun Lihua
    Asian Journal of Social Pharmacy    2025, 20 (4): 402-412.  
    Abstract13)      PDF(pc) (1363KB)(11)       Save
    Objective To systematically evaluate the overall characteristics and quality of literature on economic evaluation of drugs for type 2 diabetes, and to provide recommendations for future research and related decision-making. Methods The economic evaluation literature on drugs for type 2 diabetes based on the Chinese population were searched from CNKI, Wanfang, VIP and PubMed databases. The literature that met the inclusion criteria was selected, and the key research elements were extracted. Meanwhile, the quality of health economics studies (QHES) was used to evaluate the quality of the literature. Results and Conclusion A total of 325 articles (296 in Chinese and 29 in English) were included. Most of the studies were conducted by medical institutions (247 articles, 76.0%) and they used cost-effectiveness analysis (295 articles, 90.8%). However, most of the included literature did not report study perspective (267 articles, 90.2%). The average QHES score of the included literature was 57.29, and the quality of the literature was concentrated in “low quality” (123 articles, 37.8%) and “average quality” (138 articles, 42.5%). Literature published in English journals, or using modeling methods, or from universities had relatively higher quality. The quality of economic evaluation literature on drugs for type 2 diabetes based on the Chinese population is generally low at present. There are many problems, such as single research institutions and methods, lack of research perspectives, and no sensitivity analysis.
    Related Articles | Metrics | Comments0