Asian Journal Of Social Pharmacy

Abstract: Objective To evaluate the preventive drug use of magnesium isoglycyrrhizinate injection beyond the instructions by rapid health technology, and to provide reference for its rational clinical application. Methods The databases such as PubMed, Embase, the Cochrane Library, HowNet, Wanfang, VIP and HTA websites were searched. Two researchers screened the literature to extract data according to the inclusion and exclusion criteria. If necessary, a third researcher was consulted. The included literature was analyzed and concluded through corresponding quality evaluation. Results and Conclusion Four meta-analysis articles and five pharmacoeconomics articles were included. In terms of effectiveness, compared with the blank group and the control group (diammonium glycyrrhizinate, glutathione, and polyene phosphatidylcholine), the preventive use of magnesium isoglycyrrhizinate injection had a lower incidence of drug-induced liver injury with a more significant reduction in the levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and total bilirubin. In terms of safety, except for an economic study in which some patients had a transient increase in blood pressure during the use of magnesium isoglycyrrhizinate injection, other studies did not show the increasing risk of adverse reactions due to preventive medication. In terms of economy, the use of magnesium isoglycyrrhizinate injection for prevention of different diseases did not necessarily have economic advantages over the control group (blank group and reduced glutathione, polyene phosphatidylcholine injection, traditional Chinese medicine combined with magnesium isoglycyrrhizinate injection). In the prevention of drug induced liver injury, magnesium isoglycyrrhizinate injection used beyond the instructions has certain efficacy and safety, but it may not be the economic optimal for other different diseases.

Key words: magnesium isoglycyrrhizinate, preventive medication, rapid health technology assessment