亚洲社会药学

Objective To study the safety and effectiveness of mechanical thrombectomy and intra-arterial thrombolysis for ischemic stroke, and to provide reference for its clinical application. Methods By searching Chinese and English databases and collecting relevant clinical trial data, some articles were screened according to the inclusion and exclusion criteria, and relevant data were extracted. Then, a meta-analysis was performed. Results and Conclusion A total of 20 randomized controlled trial (RCT) studies were included, and the safety of mechanical thrombolysis was not significantly different from that of intra-arterial thrombolysis. In terms of effectiveness, the revascularization rate of mechanical thrombolysis was higher than that of intra-arterial thrombolysis, and there was no significant difference in mRS score and 14-day National Institute of Health Stroke Scale (NHISS) score. Mechanical thrombectomy, as an intravascular interventional therapy for ischemic stroke, has certain clinical advantages in improving vascular recirculation rate, but more clinical research evidence is still needed.