亚洲社会药学

本期目录

2025年, 第20卷, 第1期　刊出日期：2025-03-20 上一期   

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Evaluation Criteria and Rationality Analysis of Drug Utilization of Meropenem in a Tertiary Medical Institution in Beijing Zhang Qiming, Huang Zhe 2025 (1):  1-9.  摘要 ( 62 )   PDF(386KB) ( 40 )   Objective To establish a drug use evaluation (DUE) standard for meropenem in a tertiary medical institution in Beijing, and to analyze the use of meropenem for promoting the rational use of antibiotics. Methods A criteria of DUE of meropenem was established based on drug instructions, related guidelines and experts’ opinions. Then, 120 cases of meropenem use from January to December 2021 were selected to carry out a retrospective study. Results and Conclusion 120 cases of meropenem use involved 8 clinical departments, including 38 cases in the Department of Respiratory Medicine, 25 cases in the Department of Tuberculosis, and 20 cases in the Department of Gastroenterology. The detection rate of pathogenic microorganisms before first use was 79.17%, and the clinical treatment effectiveness rate was 81.67%. The irrational use of meropenem included poor grasp of usage indications, excessively high starting points, inappropriate usage and dosage, non-standard treatment courses, and excessive combination medication. Pharmacists should strengthen the monitoring and evaluation of carbapenem drugs such as meropenem, provide timely feedback on relevant situations, and promote rational clinical medication. 相关文章 | 计量指标

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Research on the Optimization of China’s Pharmacovigilance Organization Management Zhang Zhi, Sun Lihua 2025 (1):  10-19.  摘要 ( 48 )   PDF(3365KB) ( 34 )   Objective To analyze the problems of China’s pharmacovigilance organization system, and to provide targeted suggestions for improving it. Methods The relevant literature at home and abroad was reviewed to compared the differences in pharmacovigilance organizations in the United States, the European Union, Japan and China. Then, the problems of China’s pharmacovigilance organization management were found out. Results and Conclusion China’s pharmacovigilance organizational system has problems such as inadequate organizational setup, immature institutional construction, no coordination mechanism for pharmacovigilance practice, and industry associations of third-party organizations having no role to play. It is recommended to carry out theoretical and methodological research on the pharmacovigilance organizational system to provide practical guidance for optimizing the system with Chinese characteristics. 相关文章 | 计量指标

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An Exploration of Improving the Regulatory System for Online Pharmacy Based on New Policy Xu Jialin, Wang Shuling, Liu Jingshuo 2025 (1):  20-27.  摘要 ( 40 )   PDF(361KB) ( 11 )   Objective To analyze the current situation of drug regulation after introducing the new policy for China’s online pharmacy, and to provide reference for the regulation of online pharmacy based on the international experience. Methods Through literature research and comparative analysis, the history of policies for online pharmacy in China was investigated, and the current situation and problems of regulation for online pharmacy were explored. Results and Conclusion It is found that the body, basis and behavior of online prescription drug supervision in China should be improved. Combining experience in regulating online prescription drug at home and abroad, we provide some suggestions for the implementation of China’s online prescription drug policy by establishing a government-led multiple regulatory mechanism, standardizing the access qualifications for enterprises with business in online prescription drugs, improving the prescription inquiry and review system, and paying attention to consumer needs. 相关文章 | 计量指标

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Comparison and Suggestions on the Registration and Regulation of Biosimilars between China and the USA Cao Yizhi, Lian Guiyu 2025 (1):  28-37.  摘要 ( 35 )   PDF(610KB) ( 19 )   Objective To put forward some suggestions for improving the registration and regulation, the efficiency of evaluation, and approval of biosimilar in China so as to promote the development of biopharmaceutical industry and increase the accessibility of therapeutic drugs in China. Methods Literature related to the registration and regulation, evaluation and approval of biosimilars were sorted out to analyze the differences in China and the USA. Results and Conclusion Based on the analysis of the current situation of registration and regulation of biosimilars between China and the USA, it is suggested to improve the registration and regulation of biosimilars in China from the following four aspects: Establishing a biosimilar regulatory department, expanding the professional evaluation personnel, scientifically simplifying the registration and approval procedures, and constantly refining the types of communication meetings. 相关文章 | 计量指标

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Study on the Market Environment of Heparin and Development Suggestions in China Based on the PEST Model Han Chengcheng, Dong Li 2025 (1):  38-46.  摘要 ( 34 )   PDF(393KB) ( 12 )   Objective To analyze the market environment of heparin, and to provide reference for the development of the heparin industry in China. Methods The international market size and competition pattern of heparin was investigated first. Then, environmental analysis of it was made based on the PEST model. Results and Conclusion There is room for optimization of the relevant policies for the development of heparin industry in China. The use of heparin drugs and regulation should be further improved. In addition, the research and development ability of pharmaceutical enterprises should be enhanced, and the development strategy of heparin industry needs to be adjusted. 相关文章 | 计量指标

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Research on the Relationship between Government R&D Subsidies of Different Sub-industries in China’s Pharmaceutical Industry and Enterprises’ R&D Investment Wang Xinke, Chang Senhao, Chen Yuwen 2025 (1):  47-56.  摘要 ( 36 )   PDF(432KB) ( 25 )   Objective To empirically analyze the relationship between Government R&D funding and R&D investment of the enterprises in different sub industries of pharmaceutical industry, and to provide reference for the development of policies related to R&D funding input. Methods Granger causality test was performed using the data of relevant indicators in different sub industries of China’s pharmaceutical industry from 1995 to 2019 based on the theory of covariance. Results and Conclusion The funding of R&D from the government had a significant positive effect on their R&D funding inputs to enterprises with chemo products, Chinese patent products, and biological products. It means the improvement of government funding was beneficial in promoting the R&D investment from various sub industries of pharmaceutical industry. The order of this influence was biological products, chemo products, and Chinese patent drugs. As to chemical drugs and biological products, the government’s R&D funding and enterprises R&D funding input showed a good trend of mutual promotion in a certain lag period. The government can fully leverage its funding to promote the investment of all sub industries of pharmaceutical industry. Meanwhile, regulatory mechanisms should be refined for government funding. For the inheritance, innovation, and development of traditional Chinese medicine, the government should give more policy support than financial support. 相关文章 | 计量指标

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Study on the Impact of Digital Economy on Innovation of Pharmaceutical Companies Li Jingran, Zhang Dawei, Jia Zheng, Xing Hua 2025 (1):  57-67.  摘要 ( 29 )   PDF(627KB) ( 10 )   Objective To study the importance of digital economy to promote the innovation development of enterprises under the background of the era of information technology reform. Methods The maximum entropy method was used to measure the comprehensive level of digital economy development at provincial level. Besides, the impact of digital economy on the innovation performance of pharmaceutical industry was investigated empirically by using A-share pharmaceutical companies listed in China from 2013 to 2020 as a research sample, and the mediating mechanism of R&D investment and financing constraints on the impact was examined. Results and Conclusion It is found that digital economy is significantly and positively related to the innovation performance of enterprises. The mechanism test shows that digital economy improves innovation performance through the expansion effect of R&D investment and alleviating financing constraints. In the context that digital economy has become a new driving force for enterprise innovation, the combination of digital economy and real economy should be actively promoted, R&D investment in pharmaceutical enterprises should be increased, and financing channels should be broadened. 相关文章 | 计量指标

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Identification and Prediction of Key Technologies in Ginsenosides Based on Genetic Knowledge Persistence Algorithm Li Qian, Zhang Wenfeng, Yuan Hongmei 2025 (1):  68-79.  摘要 ( 40 )   PDF(1101KB) ( 16 )   Objective To study the key technologies in the field of ginsenosides and to offer a guide for the future development ginsenosides through the main path identification method based on genetic knowledge persistence algorithm (GKPA). Methods The global ginsenoside invention authorized patents were used as the data source to construct a ginsenoside patent self-citation network, and to identify high knowledge persistent patents (HKPP) of ginsenoside technology based on the GKPA, and extract its high knowledge persistence main path (HKPMP). Finally, the genetic forward and backward path (GFBP) was used to search the nodes on the main path, and draw the genetic forward and backward main path (GFBMP) of ginsenoside technology. Results and Conclusion The algorithm was applied to the field of ginsenosides. The research results show the milestone patents in ginsenosides technology and the main evolution process of three key technologies, which points out the future direction for the technological development of ginsenosides. The results obtained by this algorithm are more interpretable, comprehensive and scientific. 相关文章 | 计量指标

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Rapid Health Technology Evaluation of Off-label Use of Magnesium Isoglycyrrhizinate Injection Yao Lan, Li Lin, Tian Lijuan 2025 (1):  80-87.  摘要 ( 35 )   PDF(429KB) ( 11 )   Objective To evaluate the preventive drug use of magnesium isoglycyrrhizinate injection beyond the instructions by rapid health technology, and to provide reference for its rational clinical application. Methods The databases such as PubMed, Embase, the Cochrane Library, HowNet, Wanfang, VIP and HTA websites were searched. Two researchers screened the literature to extract data according to the inclusion and exclusion criteria. If necessary, a third researcher was consulted. The included literature was analyzed and concluded through corresponding quality evaluation. Results and Conclusion Four meta-analysis articles and five pharmacoeconomics articles were included. In terms of effectiveness, compared with the blank group and the control group (diammonium glycyrrhizinate, glutathione, and polyene phosphatidylcholine), the preventive use of magnesium isoglycyrrhizinate injection had a lower incidence of drug-induced liver injury with a more significant reduction in the levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, and total bilirubin. In terms of safety, except for an economic study in which some patients had a transient increase in blood pressure during the use of magnesium isoglycyrrhizinate injection, other studies did not show the increasing risk of adverse reactions due to preventive medication. In terms of economy, the use of magnesium isoglycyrrhizinate injection for prevention of different diseases did not necessarily have economic advantages over the control group (blank group and reduced glutathione, polyene phosphatidylcholine injection, traditional Chinese medicine combined with magnesium isoglycyrrhizinate injection). In the prevention of drug induced liver injury, magnesium isoglycyrrhizinate injection used beyond the instructions has certain efficacy and safety, but it may not be the economic optimal for other different diseases. 相关文章 | 计量指标

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Research on the Development Status, Problems and Countermeasures of Sports and Fitness APPs Xiu Yu, Wang Shuling 2025 (1):  88-93.  摘要 ( 34 )   PDF(380KB) ( 12 )   Objective To study the increasing use of sports and fitness APPs against the background of national fitness and post-epidemic era, and to provide some suggestions for the development of sports and fitness APPs. Methods Literature survey and mathematical statistics were used to define the concept of sports and fitness APPs, and their characteristics and advantages were investigated. Then, their problems were pointed out. Results and Conclusion The existing problems include some APPs favoring female users, single function, and slightly backward profit model. Some countermeasures such as enriching course types, taking into account all categories of users, expanding more functions, improving service quality, broadening profit channels, and improving marketing level are put forward. This can provide theoretical basis for the operation of sports and fitness APPs and better popularize the culture of national fitness. 相关文章 | 计量指标